For most of Cyberpunk 2077, you'll have free rein to take on activities in Night City in any order you please. Much of the main story is divided into parallel investigations as V tries to find people who might know about the biochip in their head, and at any point, you can wander off and work your way through a variety of side missions. At some point, though, you'll hit the end of the road. From here, the main story continues on to its conclusion, leaving you with no opportunities to do any more side content until you've reached the end.

Cyberpunk 2077 politely marks this point in the story for you, flashing a big "Point of No Return" message on your screen so you don't bumble into the game's finale before you're ready. But at the same time, Night City is absolutely overwhelmingly flush with things to do, from side jobs to Fixer gigs to question marks and NCPD scanner hustles. And if you're not interested in completing everything, or if you find yourself impatient to know how it all ends, you might be asking how much of all that side material you absolutely need to do.

The good news is that there's a lot of side quests you can ignore without consequence. The bad news is that a few of them can be pretty important to how the game shakes out, even having an effect on the ending. Here's a complete rundown of everything you should scratch off your list before you pass the Point of No Return in Cyberpunk 2077 so you can be in the best possible story shape for the endgame. It's worth noting, though, that you can continue to level up your character and earn some extremely powerful weapons through additional side quests, and pursuing that stuff might not be a bad idea. Although we tried to limit them, there are SPOILERS beyond this point!